ANALYTICAL SYSTEMS: APPLIED BIOSYSTEMS/MDS SCIEX (AB/MDS SCIEX)

Applied Biosystems/MDS SCIEX (AB/MDS SCIEX), formerly PE SCIEX and now a subsidiary of Applied Biosystems Group, offers a line of LC/MS and LC/MS/MS systems for drug discovery.

The API 150EX™ is a single quadrupole LC/MS system covering a mass range between 30-3000 Daltons. This system uses a Curtain Gas™ interface to maintain the interface and analyzer clean and prevent ion path contamination. The API 150EX™ system accepts 4 different ionization sources to cover LC flow rates from 20 nL/min to 2.0 mL/min:

• IonSpray™ for API (Atmospheric Pressure Ionization) analysis nebulizing the samples at room temperature.
• MicroIonSpray™ (µIonSpray™), an API-based source, to analyze tiny amounts of polar, thermally labile compounds.
• TurboIonSpray™ (TIS), an ElectroSpray-based source (ES), is more sensitive than IonSpray™-based source which in turn requires less material for analysis and can handle higher flow rates.
• Atmospheric Pressure Chemical Ionization (APCI) uses a Heated Nebulizer interface for higher sensitivity (down to the picogram range) to provide structural information.

The Mariner™ API-TOF Workstation is based on time-of-flight (TOF) mass analysis for high resolution detection. This system uses AB/MDS SCIEX's TurboIonSpray™ (TIS) and Atmospheric Pressure Chemical Ionization (APCI) sources and the 8-probe Gilson Multiple Probe 215 liquid handler to provide high-throughput sampling. This system can be used for the analysis of libraries for combinatorial chemistry as well as characterization of proteins, peptides, and oligonucleotides.

The API 2000™ LC/MS/MS System is a triple quadrupole mass spectrometry system also suitable for high-throughput MS/MS applications. This benchtop system is built-in with a small foot print, uses TurboIonSpray® and APCI sources, and it hanldes a mass spectrum range of 5–1,800 Daltons.

The API 3000™ LC/MS/MS System is a robust system that comes with a mass range of 30–3,000 Daltons with a mass accuracy of 0.01%.

The API 4000™ LC/MS/MS System is a triple quadrupole mass spectrometry system that uses the new Turbo V™ source to easily exchange between the APCI and TurboIonSpray® probes. This system comes with a mass range of 5-3,000 Daltons and a mass accuracy of 0.01%.

The QSTAR™ Hybrid LC/MS/MS is a robust system that combines the use of quadrupole and time-of-flight (TOF) instrumentation to accurately detect the masses of both molecular and product ions. This system allows the identification of species in a mass range of 5-12,000 Daltons. It's accuracy and sensitivity permits the analysis and detection of metabolites as well as single compounds in combinatorial mixtures (libraries).

AB/MDS SCIEX also offers its API 150EX™ Prep LC/MS System for high throughput compound characterization and purification applications. For more information on the API 150EX™ Prep LC/MS System here at CombiChem Lab click here.