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REACTION
BLOCKS: TORVIQ
Torviq
provides different systems for solid phase synthesis, including
its new ENCORE system.
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Polypropylene
syringes equipped with a sintered polypropylene
disks serve as disposable reaction vessels. Five sizes are
available: 3, 5, 10, 20, and 50-mL.
The
Teflon-made Domino blocks are reaction blocks for parallel
solid-phase synthesis that use polypropylene
syringes as reaction vessels.
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The
Domino blocks come in a microtiter plate footprint
and are available in 3 array formats:
- 2
x 3 designed for 50 mL syringes.
- 3
x 4 designed to accommodate up to 20-mL syringes.
- 4
x 6 designed to accommodate 2.5-mL and 5-mL syringes.
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Domino
blocks (Note: Torviq
cautions on the use of syringes
for overnight reactions).
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The
Domino reaction block takes up to 4 6x2-vessel racks
sitting on a shaker for a maximum throughput of 48 reactions
per cycle. The racks are designed to allow online solvent evacuation
or solvent distribution through the use of a 2- or 3-valve solvent
control. For more information on the Domino blocks click
here. |
Torviq's
Don Cucna system allows parallel solid phase synthesis
in 96 reaction vessels on 10 to 50 mg of resin. As part of this
system Torviq provides a 96-stainless-steel-needle aspirator
station for simultaneous liquid removal from 96-well plates.
For more information on this aspirator click
here. |
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For
the Don Cucna system Torviq has a 96-pin solvent dispenser
station for simultaneous addition of solvents in 96-well
plates. Solvent can be added by using a syringe or automatically
by using a manifold-containing piston pump. For more information
on this solvent dispenser station click
here. |
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Marast synthesizer allows parallel solid phase synthesis
in 4 reaction vessels on 3 to 30 g of resin. The available reactions
vessels for the La Marast synthesizer are inlcude 100
mL, 200-mL, and 450-mL conical centrifuge tubes. For more information
on La Marast synthesizer click
here. |
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Torviq
offers a gas chamber cleavage station for the release
of compounds bound to polymer supports. This gas chamber station
comes in 2 different sizes to accommodate either 13 or 3 96-well
plates. This chamber is designed to use either HF or HCl gas
to cleave polymer-bound compounds in dry allowing the final
compound uptake into a suitable solvent. For more information
on this gas chamber click
here. |
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Torviq
has also available its new ENCORE system (Encoding
by Necklace, Color and Reaction vessel)
for directed sorting combinatorial solid phase synthesis on
Mimotopes'
SynPhase™ Lanterns. The
ENCORE system is based based on a combination of three
different coding techniques.
For
the ENCORE system Torviq provides the following 5 tools
to facilitate necklace-coding combinatorial synthesis:
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The
Arraying Tool arranges 96
random Lanterns.
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The
Magazine for arrangement
and transfer of Lanterns.
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The
Lapis Tool (Lantern
Picking and Stringing) to pick Lanterns from
the Magazine an place into reaction vessels.
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Reaction
vessel loaded with 8 Lapis
tools, 10 Lanterns on one Lapis tool.
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The
Dispensing Tool to distribute
Lanterns into 96-well plates.
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The
Leveling Tool to distribute
Lanterns into cleavage plates.
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For
more information on the ENCORE concept and the ENCORE
system click
here.
Torviq
also offers protected amino acids and reagents for combinatorial
and parallel synthesis. For more information about Torviq's
building blocks here at CombiChem Lab click
here.
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