MICROREACTORS: IRORI

IRORI, a subsidiary of Discovery Partners International Inc. (DPII), offers its radio-frequency tagged prodcut line for combinatorial synthesis in drug discovery.

IRORI offers its AccuTag™-100 Sorting Station. The AccuTag™-100 comes with proprietary software, a tag reader, cables with light indicators to aid during the sorting process, radiofrequency tags, and MicroKans™.

In order to isolate discrete compounds in a 96-well plate format, IRORI offers its AccuCleave™ product line. The AccuCleave™-96 Cleavage Station for the sumultaneous cleavage of 96 compounds, the AccuCleave™-48 Cleavage Station for cleavage of up to 48 compounds.

For higher cleavage throughput IRORI also has the AccuCleave™-192 Cleavage Station. This new cleavage station is based on the AccuCleave™-96 design but with double capacity to cleave 192 microreactors simultaneously. Cleaved products can be collected into 2.4 ml Marsh Tubes or 96 deep-well square plates. (Note: IRORI recommends the use of  the AccuCleave™-192 only with MicroKans™).

IRORI's product line also includes: MultiTag-96 Tag Dropper, MicroKan Filling Kit, MultiCap-96 Capping Station, LED Sorting Indicator. For more information on these accessories click here.

And there is also the 3 kind of IRORI reactors: MicroKan™, MiniKan™,  and MacroKan™. (Note: Bohdan's MiniBlocks™ offer the capability of accommodating IRORI's Microkans™. For more information on the Bohdan MiniBlocks™ click here).

IRORI also has an automated sorter: the AutoSort™-10K. This automated equipment sorts 1,000 microreactors per hour and accommodates up to 10,000 microreactors.  The AutoSort™-10K can also sort microreactors into the AccuCleave™-96 Cleavage Station.

IRORI also offers the new AutoSort™-10KX. The new AutoSort™-10Kx can now sort automatically IRORI's microreactors directly into Bohdan MiniBlocks™. For more information on the AutoSort-10Kx contact IRORI directly.

AutoSort™-10KX.

To aid in the post-reaction steps, IRORI has its AutoWash™-10K Automated Microreactor Washing Station. This new PC-controlled washing station handles up to 10,000 MicroKans™, it handles and delivers up to 3  different solvents, and it can separate chlorinated and non-chlorinated liquid waste. 

AutoWash™-10K

IRORI also has available the KanWash-1K™ Microreactor Washer. This system is design to accommodate up to 1,000 MicroKan or 500 MiniKan reactors which can be wahsed using up to 6 different solvents.

KanWash-1K™

IRORI has available its new Dry Resin Filler. This unit consists of a shaker with a welded flat  anodized aluminum plate to accommodate pre-formatted arrays of MicroKan™ and MiniKan™ reactors. IRORI offers 3 different 96-well anodized aluminum tops, each type with different hole dimensions to accommodate reproducible amounts of dry loose resin per well. Since the resin loader is welded on a shaker, shaking the resin poured on the resin loader ensures homogenous resin distribution per well prior to resin delivery.

IRORI has now available its new NanoKan™ system.  The new NanoKans™ use a disposable 2D barcode system, hold about 8 mg of resin and afford approximately 1 mg of final product after compound cleavage. The picture on the left displays the new 2D barcode system and the size of the NanoKans™ compared to a dime.

IRORI has a page for Tips and Hints for IRORI users.

For more information on all these items click here.

ChemRx, a subsidiary of Discovery Partners International Inc. (DPII), offers its services for drug discovery. For a review of ChemRx services here at CombiChem Lab click here.