MICROREACTORS: MIMOTOPES PTY. LTD.

Mimotopes Pty. Ltd., a subsidiary of Fisher Scientific International Inc., offers its SynPhase™ line of grafted products for solid phase combinatorial chemistry:

The SynPhase™ products come in 2 types: SynPhase™ Crowns and SynPhase™ Lanterns.

SynPhase™ Crowns, named after their shape, were the first generation of grafted products available with 3 different grafted surfaces for solid phase combinatorial chemistry.

The available grafted surfaces are:

SynPhase-PS, a PolyStyrene (PS) grafted surface crown is available with the following loadings:

• O-Series Crowns with a loading of 4 µmol.
• I-Series Crowns with a loading of 18 µmol.

SynPhase-MD, a Methacrylic acid/Dimethylacrylamide (MD) co-polymer grafted surface is available with the following loadings:

• O-Series Crowns with a loading of 1-2 µmol.
• I-Series Crowns with a loading of 5-10 µmol.

SynPhase-HM, a Hydroxyethyl Methacrylate (HM) grafted surface is available with the following loadings:

• O-Series Crowns with a loading of 1-2 µmol.
• I-Series Crowns with a loading of 4-8 µmol.

The SynPhase™ Crowns are also available with several handlers and linkers. For more information on available handlers and linkers click here. For more information on the SynPhase™ Crowns click here.

The new SynPhase™ Lanterns have a new symmetrical design and an improved grafted surface and higher loadings.

The SynPhase™ Lanterns are available in 2 types:

• L-Series Lanterns with a loading of 15 µmol.
• D-Series Lanterns with a loading of 35 µmol.

For more information on the Synphase™ Lanterns click here.

Based on  radiofrequency tag technology both the Synphase™ Crowns and Lanterns can be used in split-and-mix protocols using Mimotopes' TranSort™ System. The TranSort™ package consists of a central reader unit, antenna, power supply, TranStems™ (radiofrequency tag holders) and Transponders™ (radiofrequency tags), all necessary cabling and connectors, and a Windows 95/NT-based program to organize library synthesis via directed sort strategy. For more information on the TranSort™ system click here.

TranStems™ are radiofrequency tag holders made of inert polypropylene-based tubes that protect  encapsulated glass-made Transponders™, the radiofrequency tags used for compound tracking. To increase versatility and compatibility,  the Transponders™ can be used with both the SynPhase™ Lanterns and the recently-introduced TranStems™.

For synthesis optimization Mimotopes has also available colored plastic tags. These plastic tags include colored "Cogs" and "Spindles" to be attached to Lanterns or to link 2 Lanterns if needed. "Cogs" and "Spindles" are available in 8 different colors. For more information click here.

The Synphase™ Crowns and Lanterns when attached to TranStems™ can be placed on a Stem holder for parallel cleavage in racks of tubes. For more information click here.

In order to facilitate and expedite the Stem attachment process Mimotopes offers the SynPhase Press to assemble simultaneously 96 Lanterns in an 8x12 array format. For more information on the SynPhase Press click here.

Also, to facilitate the rapid, safe and simultaneous removal of 96 Stems™ or TranStems™ from Lanterns™ or I-Series Crowns Mimotopes offers the Stem Recycler. For more information click here.

The Synphase™ Crowns and Lanterns can be used with Mimotopes' Multipin™ synthesis format for parallel 8x12 array synthesis and parallel cleavage. To read more about the Multipin™ synthesis format click here.

For more information of Mimotopes' products for combinatorial chemistry click here.

For more information on Mimotope's MultiPin™ reaction system here at CombiChem Lab click here.