MICROWAVE SYSTEMS: PERSONAL CHEMISTRY

Personal Chemistry offers its microwave-assisted Coherent Synthesis™ system technology to expedite combinatorial chemistry synthesis and drug discovery.

Microwave-assisted synthesis is gaining acceptance in the drug discovery process due to all the advatanges it provides compared to traditional systesis. Some of the advantages that microwave-assisted synthesis provides include short reaction times, solvent-free reactions and the use of less reactive agents.

Since microwave-assisted synthesis are done under high-temperature and high-pressure conditions, both the SmithCreator™ and the SmithSynthesizer™ use the SmithProcessVials™. The SmithProcessVials™, which can accomodate a magnetic stirring bar, are made of inert material to avoid systhtesis contamination, resist pressures up to 20 bars, and their design allow even energy distribution throughout the entire reaction volume. For more information on the SmithProcessVials™ click here.

The SmithCreator™ aids in the development and optimization of synthetic methodologies which in turc can be transferred to the SmithSynthesizer™ for further development work. For more information on the SmithCreator™ click here. To see a Quicktime™ animation of SmithCreator™ (1.0 Mb) click here.

The SmithSynthesizer™ is a high-throughput synthesis workstation that comes with an integrated liquid handler, a built-in temperature and pressure sensors to monitor and control individual reaction vessels, and space to accommodates up to 5 racks to process up to 120 reactions in single vials. The average throughput of the Smith Synthesizer™ is about 12-15 reactions/hour. For more information on the Smith Synthesizer™ click here.

Personal Chemistry has now available its Emrys™ Knowledge Builder. The Emrys™ Knowledge Builder is a knowledge management system for the Coherent Synthesis™ that in addition to capture and manage synthetic information, all captured synthetic protocols can be executable on the SmithSynthesizer™. For more information on the Emrys™ Knowledge Builder click here and here.

Personal Chemistry has also availabe its Emrys™ PathFinder which contains thousands of verified reactions that can be executed with its Coherent Synthesis™ system. For more information on the Emrys™ PathFinder click here.

For more information on the Coherent Synthesis™ system click here.

Personal Chemistry also offers its SmithReactionKit™ for the SmithCreator™ and SmithSynthesizer™ workstations. For a review of the SmithReactionKit™ here at CombiChem Lab click here.