SYSTEMS: PERSONAL CHEMISTRY
Chemistry offers its microwave-assisted Coherent
Synthesis system technology to expedite combinatorial
chemistry synthesis and drug discovery.
synthesis is gaining acceptance in the drug discovery process due
to all the advatanges it provides compared to traditional systesis.
Some of the advantages that microwave-assisted synthesis provides
include short reaction times, solvent-free reactions and the use
of less reactive agents.
microwave-assisted synthesis are done under high-temperature
and high-pressure conditions, both the SmithCreator
and the SmithSynthesizer use the SmithProcessVials.
The SmithProcessVials, which can accomodate a magnetic
stirring bar, are made of inert material to avoid systhtesis
contamination, resist pressures up to 20 bars, and their design
allow even energy distribution throughout the entire reaction
volume. For more information on the SmithProcessVials
SmithCreator aids in the development and optimization
of synthetic methodologies which in turc can be transferred
to the SmithSynthesizer for further development
work. For more information on the SmithCreator
here. To see a Quicktime
animation of SmithCreator (1.0 Mb) click
SmithSynthesizer is a high-throughput synthesis
workstation that comes with an integrated liquid handler, a
built-in temperature and pressure sensors to monitor and control
individual reaction vessels, and space to accommodates up to
5 racks to process up to 120 reactions in single vials. The
average throughput of the Smith Synthesizer is
about 12-15 reactions/hour. For more information on the Smith
Chemistry has now available its Emrys Knowledge Builder.
The Emrys Knowledge Builder is a knowledge management
system for the Coherent Synthesis that in addition to
capture and manage synthetic information, all captured synthetic
protocols can be executable on the SmithSynthesizer.
For more information on the Emrys Knowledge Builder
here and here.
Chemistry has also availabe its Emrys PathFinder which
contains thousands of verified reactions that can be executed with
its Coherent Synthesis system. For more information on the
Emrys PathFinder click
more information on the Coherent Synthesis system click
Chemistry also offers its SmithReactionKit
for the SmithCreator
workstations. For a review of the SmithReactionKit
here at CombiChem Lab click