NEWS: AUGUST 2003

-8/29/2003-

Press Release: ASINEX Announces Drug Discovery Collaboration with F2G Ltd. To read press release click here. ASINEX offers a large collection of highly pure and diverse small organic compounds for CombiChem and HTS as well as its services for chemistry and drug discovery. For a review of ASINEX's compound collections and services here at CombiChem Lab click here.

-8/28/2003-

The Strategic Research Institute (SRI) will host the "Angiogenesis: New Opportunities & Solutions for Drug Development" conference on September 29-30, 2003, in Cambridge, MA. To read article click here. SRI promotes and hosts a broad range of scientific oriented conferences. For more information on SRI here at CombiChem Lab click here.

Two bombs explode at Chiron Corp. Animal rights activists suspected in Chiron blasts. To read article click here.

Roche appoints Robert B. Stein, M.D., Ph.D., as president of Roche Palo Alto. To read article click here.

IMI International Medical Innovations Inc. and AtheroGenics Inc. form research collaboration. To read article click here.

Myogen Inc. goes IPO. To read article click here.

Cellegy Pharmaceuticals Inc. receives U.S. patent 6,610,652 entitled "Microdose Therapy." for the treatment of female sexual dysfunction. To read article click here.

Study indicates that chromium picolinate improve insuline uptake in patients with Type 2 Diabetes by increasing the phosphorylation of the Akt protein. To read article click here.

-8/27/2003-

IBC to host the "Antibody Therapeutics -- From Clinical Development to Business Strategies" conferences on December 1-2, 2003, in San Diego, CA. For more information on this conference click here. IBC promotes and hosts a broad range of scientific oriented conferences. For more information on IBC here at CombiChem Lab click here.

BioCryst Pharmaceuticals Inc. terminates collaboration with 3-Dimensional Pharmaceuticals Inc. (3DP). To read article click here.

FDA approves new dosage of Avandamet™ (rosiglitazone maleate and metformin HCl) for Type 2 Diabetes. To read article click here.

Genentech Inc. and Amgen Inc. settle patent dispute on Neupogen® and Neulasta®. To read article click here.

Genaera Corporation receives U.S. patent 6,610,866 for the synthesis of squalamine intermediates. To read article click here.

Bcl10 gene found to play key role in B cell development and cancer. To read article click here.

-8/26/2003-

The Strategic Research Institute (SRI) will host the "3rd Annual Pharma & Biotech Business Intelligence Summit" conference on September 18-19, 2003, in Princeton, NJ. To read article click here. SRI promotes and hosts a broad range of scientific oriented conferences. For more information on SRI here at CombiChem Lab click here.

Argonaut Technologies Inc. will present workshop entitled "Integrated Chemical Discovery and Development: Synthesis through Purification" at the upcoming American Chemical Society meeting in September 2003. To read article click here. Argonaut Technologies provides chemical and reagents as well as semiautomated synthesizers for parallel synthesis. For a review of Argonaut Technologies' chemicals and semiautomated synthesizers here at CombiChem Lab click here and here, respectively.

Geron Corporation receives U.S. patent 6,610,839 covering human telomerase promoter. To read article click here.

Phase Bioscience receives SBIR grant to develope novel enzyme carriers. To read article click here.

The American Chemical Society names 3 scientits from Abbott Laboratories heroes for their discovery of HIV therapy Kaletra® (Lopinavir/Ritonavir). To read article click here.

Incyte Corporation names Richard Levy, M.D., senior vice president, drug development. To read article click here.

Celgene Corporation receives U.S. patent 6,610,505 covering identification techniques of compounds that influence JNK protein kinase activity. To read article click here.

Thomson ISI ResearchSoft ships EndNote Version 7 for Macintosh OS X. To read article click here.

-8/25/2003-

The Strategic Research Institute (SRI) will host the "8th Drug Delivery Technologies & Deal-Making Summit" conference on September 15-17, 2003, in Cherry Hill, NJ. To read article click here. SRI promotes and hosts a broad range of scientific oriented conferences. For more information on SRI here at CombiChem Lab click here.

The Strategic Research Institute (SRI) will host the "7th International Outsourcing of Pharmaceutical Chemistry & Drug Discovery" conference on September 29-30, 2003, in Cherry Hill, NJ. To read article click here. SRI promotes and hosts a broad range of scientific oriented conferences. For more information on SRI here at CombiChem Lab click here.

ChemNavigator Inc. receives notice of allowance on 3-DPL™ Map patent. To read article click here.

ICN Pharmaceuticals Inc. completes the acquisition of Ribapharm Inc. To read article click here.

FDA approves ENBREL® (etanercept) as first therapy to inhibit bone and joint damage in patients with psoriatic arthritis. To read article click here.

Genaera Corporation's Senior Vice President and Chief Financial Officer resigns. To read article click here.

-8/22/2003-

The Strategic Research Institute (SRI) will host the "Protease Targets and Drug Discovery" conference on December 8-9, 2003, in Philadelphia, PA. To read article click here. SRI promotes and hosts a broad range of scientific oriented conferences. For more information on SRI here at CombiChem Lab click here.

Schering-Plough to cut 1000 jobs. To read article click here.

Invitrogen Corp. acquires Molecular Probes Inc. for $325 million. To read article click here.

Abbott Laboratories Inc. to spin off the less profitable parts of its hospital products division. To read article click here.

Incyte Corp. 's President, Chief Scientific Officer and Director Dr. Robert Stein resigns. To read article click here.

Julian Adams will leave his position as senior vice president at Millennium Pharmaceuticals to join Infinity Pharmaceuticals Inc as CSO. To read article click here.

-8/21/2003-

The Strategic Research Institute (SRI) will host the first Phosphodiesterase Conference on November 13-14, 2003, in Princeton, NJ. To read article click here. SRI promotes and hosts a broad range of scientific oriented conferences. For more information on SRI here at CombiChem Lab click here.

Class action suit filed against Tripos Inc. for allegedly providing false and misleading information to the investing community. To read article click here. Tripos Inc. provides a suite of software tools for combinatorial chemistry and drug discovery. For a review of Tripos' software tools here at CombiChem Lab click here.

GenVec Inc. and Diacrin Inc. merge. To read article click here.

Eli Lilly & Co. to invest $322 million in head quarters expansion. To read article click here.

-8/20/2003-

IBC to host the "14th Annual International Antibody Engineering" conferences on November 30 - December 3, 2003, in San Diego, CA. For more information on this conference click here. IBC promotes and hosts a broad range of scientific oriented conferences. For more information on IBC here at CombiChem Lab click here.

Johnson & Johnson wins $700 million stents patent dispute. To read article click here.

Merck spins off Medco Health Solutions Inc. To read article click here.

First-ever gene therapy for Parkinson's takes off at NewYork Weill Cornell Medical Center. To read article click here.

-8/19/2003-

The Strategic Research Institute (SRI) will host the "Outsourcing of Clinical Drug Development" conference on September 15-17, 2003, in Scottsdale, AZ. To read article click here. SRI promotes and hosts a broad range of scientific oriented conferences. For more information on SRI here at CombiChem Lab click here.

The Strategic Research Institute (SRI) will host the "Nucleic Acid World Summit" conference on September 22-24, 2003, in Boston, MA. To read article click here. SRI promotes and hosts a broad range of scientific oriented conferences. For more information on SRI here at CombiChem Lab click here.

Illumina Inc. releases its new SNP-based Linkage III Panel for linkage mapping. To read article click here.

Gene Logic Inc. and the FDA to work together to establish RNA standards for toxicogenomics data. To read article click here.

FDA gives fast track designation to Human Genome Sciences Inc.'s ABthrax for the prevention and treatment of anthrax infections. To read article click here.

Geron Corporation receives U.S. patent 6,608,036 covering prroprietary oligonucleotides that inhibit human telomerase. To read article click here.

NicOx SA and Merck & Co. Inc. form research collaboration for nitric oxide-donating compounds. To read article click here.

-8/18/2003-

Invitrogen Corp. get approval for the acquisition of Molecular Probes Inc. To read article click here.

PanGeo Pharma Inc. receives approval to sale its natural health products business to Jamieson Laboratories Ltd. To read article click here.

Kemia Inc. names Lewis J. Shuster President and CEO. To read article click here.

ChemCodes Inc. and VM Discovery Inc. form alliance. To read article click here.

-8/15/2003-

Press Release: Scientists from Guava Technologies earlier this week presented research at the Drug Discovery technology meeting in Boston, MA, USA demonstrating the use of the Guava PCA-96 to rapidly, precisely and objectively perform single cell analysis using a variety of applications. To read press release click here.

Press Release: INTEGRA Holdings AG has announced the successful completion of the reorganisation of its INTEGRA Biosciences AG business. To read press release click here.

Abbott Laboratories Inc. and Millennium Pharmaceuticals Inc. terminate diabetes and obesity drug research collaboration. To read article click here.

Protein Design Labs Inc. fights Genentech Inc. over the rights to a recently approved asthma drug Xolair. To read article click here.

Bayer AG to sell its Walothen GmbH subsidiary to the Wihuri group of Finland. To read article click here.

-8/14/2003-

Press Release: Guava Technologies has announced that its popular MultiCaspase, TUNEL, and Cell Cycle assays are now available in the 96-well microplate format for use with the Guava PCA-96 system. To read press release click here.

The Strategic Research Institute (SRI) will host the "Oncology & Antibody Business Development Global Summit" conference on October 20-21, 2003, in Philadelphia, PA. To read article click here. SRI promotes and hosts a broad range of scientific oriented conferences. For more information on SRI here at CombiChem Lab click here.

CancerVax Corporation goes public. To read article click here.

Genta Incorporated to acquire Salus Therapeutics Inc. To read article click here.

Corixa Corp. and Apovia AG form research collaboration on Adjuvant (RC-529). To read article click here.

ImClone Systems Inc. resubmits colon cancer drug Erbitux™ (cetuximab) to the FDA. To read article click here.

Thesis Chemistry LLC and Daicel Chemical Industries Ltd. sign collaborative business development agreement. To read article click here.

AVI BioPharma Inc. files to the FDA for orphan drug status for its SARS coronavirus antisense drug AVI-4179. To read article click here.

Gilead Sciences Inc. to acquire its campus in Foster City, California, for $123 million. To read article click here.

Generex Biotechnology Corporation receives SBIR grant to develop HER-2/neu peptide vaccine for breast cancer. To read article click here.

-8/13/2003-

Press Release: The new Guava PCA-96 AFP (Auto-Fluorescing Protein) system allows researchers to determine the relative levels of fluorescing proteins produced by individual cells in a culture and to screen 96 such cultures in a single instrument run. To read press release click here.

Press Release: Boehringer Ingelheim Pharmaceuticals Inc. announced as a SciTegic® customer. To read press release click here.

FDA blocks Pfizer Inc. bid for liquid form of Geodon for schizophrenia. To read article click here.

-8/12/2003-

Argonaut Technologies Inc. introduces new technology for compound purification. To read article click here. Argonaut Technologies provides chemical and reagents as well as semiautomated synthesizers for parallel synthesis. For a review of Argonaut Technologies' chemicals and semiautomated synthesizers here at CombiChem Lab click here and here, respectively.

Pharmacopeia Inc., in collaboration with Bristol-Myers Squibb Co., files IND application for p38 kinase inhibitor for rheumatoid arthritis treatment. To read article click here. Pharmacopeia Inc. provides services for drug discovery R&D. For a review of Pharmacopeia's services here at CombiChem Lab click here.

FDA approves AstraZeneca's CRESTOR® (rosuvastatin calcium) to lower LDL cholesterol levels. To read article click here.

Synthematix® Inc. signs Incyte Corporation to adopt and use Synthematix's Arthur™ Suite throughout Incyte's chemistry R&D. To read article click here.

CombiMatrix launches siRNA solutions for drug discovery research. To read article click here.

-8/11/2003-

Press Release: At Drug Discovery Technology 2003, Guava Technologies, Inc. today introduced the Guava ViaCount RCS assay, a new software option for the Guava PCA and Guava PCA-96 systems that fully automates data analysis for cell counting and viability testing. To read press release click here.

Press Release: Genetix have announced new low profile 384-well plates adding to their range of high quality plastic microplates for use in bioresearch applications. To read press release click here.

Press Release: Located at www.porvair-sciences.com the recently updated website from Porvair Sciences is a must bookmark site for users of microplates and microplate technology in Life Science, Solid Phase Extraction, Chromatography and HTS laboratories. To read press release click here.

IBC's 8th Annual World Congress on Drug Discovery Technology™ begins in Boston, MA. To read article click here. IBC promotes and hosts a broad range of scientific oriented conferences. For more information on IBC here at CombiChem Lab click here.

Agilent Technologies Inc. and Paradigm Genetics Inc. introduce 60-mer oligonucelotide mouse microarray kit for genome-wide profiling research. To read article click here. Agilent Technologies provides high-throughput HPLC analytical systems for combinatorial chemistry and drug discovery. For a review of Agilent's analytical systems here at CombiChem Lab click here.

Agilent Technologies Inc. introduces the Multiple Affinity Removal System to remove simultaneously six high-abundance proteins from human blood serum. To read article click here. Agilent Technologies provides high-throughput HPLC analytical systems for combinatorial chemistry and drug discovery. For a review of Agilent's analytical systems here at CombiChem Lab click here.

Tripos Inc. releases ChemCoreRIO™, ChemCoreREG™ and the Tripos Electronic Notebook™. To read article click here. Tripos Inc. provides a suite of software tools for combinatorial chemistry and drug discovery. For a review of Tripos' software tools here at CombiChem Lab click here.

Molecular Devices Corp. introduces the SpectraMax® M2, a multi-detection microplate reader with dual-mode cuvette port for fluorescence and absorbance assays. To read article click here.

Cellomics Inc. appoints Dan Calvo as President and CEO. To read article click here.

Neurion Pharmaceuticals Inc. embraces Axon Instruments Inc.'s OpusXpress 6000A ion channel screening platform to expedite unnatural amino acid drug discovery programs. To read article click here.

Spectral Genomics Inc. appoints Dr. Ed Chait as new CEO. To read article click here.

Wyeth returns to Transkaryotic Therapies Inc. european rights for hemophilia therapy. To read article click here.

Generex Biotechnology Corporation completes the acquisition of Antigen Express Inc. To read article click here.

-8/08/2003-

Press Release: A new 6-page brochure describing a comprehensive selection of deep-well plates, sealing and storage products is now available from Porvair Sciences Ltd. To read press release click here.

Press Release: A new highly intuitive software package offering many advanced features has been announced by ESA Analytical, a leading supplier of advanced separations, detection and analysis systems, for its highly sensitive and selective CoulArray HPLC electrochemical array detector. To read press release click here.

The Strategic Research Institute (SRI) will host the 4th International "Protein Kinases in Drug Discovery & Development" conference on October 20-22, 2003, in Philadelphia, PA. To read article click here. SRI promotes and hosts a broad range of scientific oriented conferences. For more information on SRI here at CombiChem Lab click here.

FDA grants OSI Pharmaceuticals-Genentech's Terceva (erlotinib HCl) orphan drug status for brain cancer treatment. To read article click here.

Elite Pharmaceuticals Inc. and Nostrum Pharmaceuticals Inc. in merger talks. To read article click here.

Novavax Inc. names Nelsom Sims as president and CEO. To read article click here.

Nature Technology Corporation receives $142,000 Small Business Innovation Research (SBIR) grant to develope gene targeting technology. To read article click here.

-8/07/2003-

Press Release: Genevac has begun delivery of a new robotic centrifugal evaporator designed to help accelerate compound purification, plate re-formatting and plate replication. To read press release click here. Genevac Ltd. provides high-throughput centrifugal evaporation systems for combinatorial chemistry, high-throughput screening (HTS) and drug discovery. To read a review of Genevac's systems here at CombiChem Lab click here.

Press Release: Lab Automation Europe 2003 at Olympia (London, UK) in November will mark the first UK public showing of the new Freedom EVO robotic liquid handling workstation from Tecan (UK). To read press release click here. Tecan provides the ChemSystem workstation and the TECAN MiniPrep systems for combinatorial chemistry and drug discovery. To read a review of TECAN's systems here at CombiChem Lab click here.

Press Release: Guava Technologies Inc, a company focused on changing the way that cell analysis is performed, and Partners HealthCare, an integrated healthcare delivery system, today announced they have formed a clinical research alliance. To read press release click here.

Pyrosequencing AB acquires Personal Chemistry. To read article click here. Personal Chemistry offers its microwave-assisted Coherent Synthesis™ system technology to expedite combinatorial chemistry synthesis and drug discovery. For a review of Personal Chemistry's systems here at CombiChem Lab click here.

Ceregene Inc. acquires exclusive worldwide rights to Salk Institute's amyotrophic lateral sclerosis (ALS) gene therapy technology. To read article click here.

Cambrex Corp. to sell its Rutherford Chemicals unit to Arsenal Capital Partners for $64 million. To read article click here.

FDA approves Novartis Pharmaceuticals's Trileptal® (oxcarbazepine) for treatment of epilepsy in children. To read article click here.

Ovation Pharmaceuticals Inc. acquires Mebaral® (mephobarbital), Chemet® (succimer), and Winstrol® (stanozolol, USP) from Sanofi-Synthelabo Inc. To read article click here.

NeurogesX names Anthony A. DiTonno CEO. To read article click here.

Inpharmatica Ltd and Ionix Pharmaceuticals Ltd sign ADME agreement. To read article click here.

-8/06/2003-

The Strategic Research Institute (SRI) will host the "Nucleic Acid World Summit" conference on September 15-17, 2003, in Boston, MA. To read article click here. SRI promotes and hosts a broad range of scientific oriented conferences. For more information on SRI here at CombiChem Lab click here.

The Strategic Research Institute (SRI) will host the "Outsourcing of Clinical Drug Development" conference on September 22-24, 2003, in Scottsdale, AZ. To read article click here. SRI promotes and hosts a broad range of scientific oriented conferences. For more information on SRI here at CombiChem Lab click here.

Infotrieve now delivers articles from all of the publications ranked as the "highest-impact journals of the decade" by Thomson ISI. To read article click here.

SurroMed Inc. receives SBIR grant for proposal entitled "Genetic Architecture of Autoimmune Diseases." To read article click here.

-8/05/2003-

IBC to host the "3rd International conference on Small Molecule & Protein Structure-Based Drug Discovery" conference on October 8-10, 2003, in San Diego, CA. For more information on this conference click here. IBC promotes and hosts a broad range of scientific oriented conferences. For more information on IBC here at CombiChem Lab click here.

Caliper Technologies Corp. lays off 9% of its work force. To read article click here.

Norak Biosciences Inc. acquires LION bioscience AG's ChemFolio® library containing more than 500,000 compounds. To read article click here. LION offers its iDiscovery™ technologies and services for drug discovery. For a review of Lion's services here at CombiChem Lab click here.

Exelixis Inc. and Dow AgroSciences LLC extend research collaboration for 1 more year. To read article click here.

Merck announces the spin off Medco in the next two weeks. To read article click here.

Serenex Inc. and Eli Lilly & Company form research collaboration. To read article click here.

Isotechnika Inc. receives U.S. patent number 6,605,593 regarding its regarding its novel immunosuppressive compound ISA247. The patent is entitled "Deuterated Cyclosporine Analogs and their use as Immunomodulating Agents." To read article click here.

-8/04/2003-

Abbott Laboratories and LigoCyte Pharmaceuticals Inc. form monoclonal antibody research collaboration. To read article click here.

Genzyme Corp. acquires SangStat Medical Corp. for about $600 million. To read article click here.

Gilead Sciences Inc. and Chiron Corporation sign non-exclusive HCV licensing agreement. To read article click here.

NeoGenesis Pharmaceuticals Inc. and Amgen Inc. form drug discovery research collaboration. To read article click here.

Advancis Pharmaceutical Corporation goes IPO. To read article click here.

-8/1/2003-

Press Release: Genevac Ltd. announces the availability of a new Inert Purge unit for its EZ-2 range of solvent evaporators. To read press release click here. Genevac Ltd. provides high-throughput centrifugal evaporation systems for combinatorial chemistry, high-throughput screening (HTS) and drug discovery. To read a review of Genevac's systems here at CombiChem Lab click here.

Press Release: Freedom EVO from Tecan (UK) is a new series of powerful laboratory workstations designed to deliver an unmatched range of automated applications in genomics, proteomics, drug discovery and clinical diagnostics. To read press release click here. Tecan provides the ChemSystem workstation and the TECAN MiniPrep systems for combinatorial chemistry and drug discovery. To read a review of TECAN's systems here at CombiChem Lab click here.

The Strategic Research Institute (SRI) will host the "Nucleic Acid World Summit" conference on Septemebr 15-17, 2003, in Boston, MA. To read article click here. SRI promotes and hosts a broad range of scientific oriented conferences. For more information on SRI here at CombiChem Lab click here.

The Strategic Research Institute (SRI) will host the "Angiogenesis: New Opportunities & Solutions for Drug Development" conference on Septemebr 29-30, 2003, in Boston, MA. To read article click here. SRI promotes and hosts a broad range of scientific oriented conferences. For more information on SRI here at CombiChem Lab click here.

Schering-Plough Corp. loses several Claritin patent claims in court. To read article click here.

ViroLogic Inc. receives 3 SBIR grants for about $3 million to develope analytical and database tools for HIV research. To read article click here.

Evotec Neurosciences GmbH and Takeda Chemical Industries Ltd. sign 4-year Alzheimer's research collaboration. To read article click here.