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FOR IMMEDIATE RELEASE November 19, 2003. A new technical note from ESA describes how the company has applied its unique products and expertise in bioanalytical detection to provide the tools to easily and quickly test early stage drug discovery compounds for their oxidative stability. Easy and Accurate Determination of a Compound's Oxidative Stability … A new technical note from ESA describes how the company has applied its unique products and expertise in bioanalytical detection to provide the tools to easily and quickly test early stage drug discovery compounds for their oxidative stability. A key parameter for the use of any compound as a drug is that of its inherent chemical stability. This stability can include everything from a measurement of a compound's stability under oxidative conditions, to the testing of a compound under artificial "forced degradation" conditions. The new technical note illustrates how ESA coulometric array systems can provide researchers with a path to quickly eliminate "problem" compounds with undesirable stability characteristics. The uniquely sensitive and selective coulometric array technology can provide researchers with important new information in regards to a compound's expected degradation pattern and predicted breakdown products by evaluating the stability of virtually any compound to oxidative degradation Simple-to operate and control the CoulArrayâ detector from ESA readily integrates with any HPLC or Bioanalytical MS system. With picogram levels of sensitivity the CoulArrayâ detector requires a minimal amount of compound for operation. In today's biophysical characterisation laboratory the ability to make rapid decisions about a compound is paramount. To this end, the ESA CoulArray® detector is capable of fast and accurate predictions of a compound's oxidation patterns, the production of degradation products and identification of "susceptible" molecules or functional groups in respect to oxidative metabolism.
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