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FOR IMMEDIATE RELEASE February 17, 2004. Available from ESA is a new technical paper discussing how coulometric electrochemical (EC) array detection is providing major bioanalytical advances in the fields of metabolomics and metabolic profiling. Electrochemical Array detection advances Metabolomics … Available from ESA is a new technical paper discussing how coulometric electrochemical (EC) array detection is providing major bioanalytical advances in the fields of metabolomics and metabolic profiling.
The paper details how the use of redox metabolic profiling, using liquid chromatography with electrochemical detection alone or in conjunction with nuclear magnetic resonance (NMR) or LC-mass spectrometry (LC-MS) has proven to be a valuable method for identifying marker compounds of disease and for studying the effects of drugs in biological systems. Using a series of examples the paper demonstrates how ESA's CoulArrayTM EC array detection technology can provide effective yet easy-to-use analysis and interpret information about important diseases such as ALS, cerebral palsy, autism and diabetes. CoulArrayTM technology is unique in that it uses a series of highly efficient coulometric electrochemical cells to specifically monitor metabolically active small molecule cellular components. The specificity of the technology can be used to greatly simplify the inherent complexity of metabolomics samples by filtering out mundane cellular components and focusing on disease markers. The unique design and properties of the CoulArrayTM also facilitate easy data analysis of these types of often highly complex samples. In addition, the CoulArrayTM offers the advantage of being able to distinguish minute changes in metabolomics patterns and components. The powerful and novel compound detection capabilities of the technology coupled with easy integration into bioanalytical systems and high throughput capacity makes the use of EC array detection a very efficient method for performing metabolomics and other important metabolic studies.
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