FOR IMMEDIATE RELEASE

February 20, 2004.

Metabolon Inc., a pioneer in the area of metabolomics research, has announced that it has decided to adopt the CoulArrayTM technology from ESA as an important component in the company's efforts to identify and monitor small molecule cellular biomarkers of disease and disease treatment.

CoulArray technology selected for key Metabolomics studies …

Metabolon Inc., a pioneer in the area of metabolomics research, has announced that it has decided to adopt the CoulArrayTM technology from ESA as an important component in the company's efforts to identify and monitor small molecule cellular biomarkers of disease and disease treatment.

The CoulArrayTM technology is unique in that it uses a series of highly efficient coulometric electrochemical cells to specifically monitor metabolically active small molecule cellular components. The CoulArrayTM system can be used to greatly simplify the inherent complexity of metabolomics samples by filtering out mundane, "house-keeping" cellular components. The unique design and properties of the CoulArrayTM also facilitate easy data analysis of these types of often highly complex samples. In addition, the CoulArrayTM offers the advantage of being able to distinguish minute changes in metabolomics patterns and components.

Walter DiGiusto, CEO of ESA, Inc., said, "We are delighted with Metabolon's choice of the CoulArrayTM for their use in metabolomics studies. Their selection of the CoulArrayTM demonstrates the utility of ESA technology in metabolomics studies, and represents the latest development in our work with Metabolon to accelerate their operations and expand their bioanalytical capabilities."

John Ryals, CEO of Metabolon, said, "The CoulArrayTM technology from ESA will be a significant component in our metabolomics technology platform. We are pleased to continue our relationship with ESA as we move forward in this important science."

European HQ ESA Analytical Ltd. Brook Farm Dorton, Aylesbury Bucks. HP18 9BH UK tel. +44-1844-239381 email: egoodall@esainc.com www.esainc.com