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FOR IMMEDIATE RELEASE July 4, 2005. Guava Technologies have introduced, for scientists in drug discovery and oncology research, four new options for assessing cellular function including mitochondrial membrane potential, cellular proliferation, and activation of caspase 3/7 or 8 enzymes. New options for productive assessment of cellular function .. Guava Technologies have introduced, for scientists in drug discovery and oncology research, four new options for assessing cellular function including mitochondrial membrane potential, cellular proliferation, and activation of caspase 3/7 or 8 enzymes.
Designed for their flagship system, the Guava EasyCyte benchtop microcytometry system, the four new assays expand Guava's current suite of assays for assessing cellular function in cancer-related areas of research and will have important applications in other areas as well. The EasyCyte's 96-well microplate analysis format enables a single researcher to easily perform hundreds of cell-based assays of differing types in a single day. The new assays further enhance Guava's existing assay menu that already provides a great deal of flexibility for investigators. With a single platform, researchers can easily interrogate multiple functional parameters in the cell in the context of absolute cell counts, sub-population analyses, and viability. The current menu of assays, which include cell cycle, apoptotic indicators and proliferation, provides a comprehensive tool set for researchers investigating cell growth and cell death. All four of the new assays bear Guava's trademark robustness and easy of use. The new mix-and-read Guava MitoPotential™ Assay measures changes in the ion gradient across the mitochondrial membrane. These gradient changes typically indicate early stages of apoptosis, or cell death, and are significant for understanding a number of diseases including multiple cancers, diabetes, and rheumatoid arthritis. Guava's Caspase 8 and Caspase 3/7 Assays detect the initial and mid-stages of programmed cell death, and, in conjunction with Guava's other cell death assays, allow researchers to more finely dissect the cellular suicide effects that drug compounds have on cells. Guava CellGrowth™ Assay - a cell proliferation assay - provides easy, reliable measurements of cellular division out to several generations. Current plate reader-based proliferation assays cannot detect if sub-populations within a sample are actively dividing or even alive; Guava CellGrowth Assay provides viability information as well as absolute counts of each generation of daughter cells, providing a more complete picture of the growth of the cell sample. The four new Guava assays all run on the Guava EasyCyte, a compact and flexible five-parameter system. Because only a few microlitres of sample are required, the Guava EasyCyte saves precious and expensive cells, reagents and compounds. The system is so easy to use that results are generated with less than a day's training. The Guava EasyCyte system runs each of Guava's turnkey assays, enabling fast and easy measurements of cell counting/viability; GFP expression and viability; apoptosis; cell cycle analysis; antigen detection; cell tracking; and more. Guava
Technologies, Inc., a privately held biotechnology and medical device
company, is the leading provider of on-demand, easy-to-use single
cell analysis systems. Guava Personal Cell Analysis (PCA™) systems,
including the Guava PCA, Guava PCA-96 and Guava EasyCyte systems,
are integrated, fully optimised, micro-capillary cytometry systems
with embedded absolute cell counting capability. Used worldwide
by the life sciences, biotechnology, and pharmaceutical industries,
as well as clinical testing institutions (outside the United States
and Europe), Guava's products have broad applications in scientific
research and throughout the drug discovery and lead optimisation
process, as well as for cell counting and optimisation of commercial
bio-pharmaceutical production. Guava offers a variety of assays
and dedicated software modules for the Guava PCA systems, enhancing
the system's overall ease-of-use. More information about the company
and its products is available at www.guavatechnologies.com.
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